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Endocrine Pathology Online

Pathology of Thyroid Non-Hodgkin's Lymphoma

Dr Sampurna Roy MD      





Nearly all primary non-Hodgkin's lymphomas of the thyroid develop on a background of Hashimoto's thyroiditis.

They are lymphomas of the Mucosa Associated Lymphoid Tissues (MALT).

Their constituent cells are usually centrocyte-like, although higher grade types are possible.

Recognition is on the basis of a lymphocytic infiltrate overrunning the gland with extensive lympho-epithelial lesions in surviving follicles and vascular invasion by the lymphocytes.

There is usually no Hurthle cell metaplasia like that seen in pure Hashimoto's thyroiditis.

Immunohistochemistry for low molecular weight cytokeratins is of value in highlighting lympho-epithelial lesions.

Immunohistochemical demonstration of monoclonality as evidenced by light chain restriction (and molecular biological techniques) are valuable in difficult cases.

The prognosis of MALT lymphomas of the thyroid is generally better than when the gland is involved by "ordinary" lymphoma.


Further reading

Outcomes of primary thyroid non-Hodgkin's lymphoma: a series of nine consecutive cases.

Identification of primary thyroid lymphoma with medical imaging: A case report and review of the literature.

Primary thyroid diffuse large B-cell lymphoma coexistent with papillary thyroid carcinoma: A case report.

[Primary thyroid extranodal marginal zone lymphoma].

[A clinical analysis of 40 cases of primary and secondary pulmonary lymphoma].

Clinicopathological features of 171 cases of primary thyroid lymphoma: a long-term study involving 24553 patients with Hashimoto's disease.

Primary thyroid lymphoma: a report of two cases.

The incidence of primary thyroid lymphoma in thyroid malignancies.

[Clinicopathologic features of primary thyroid lymphoma].

Primary thyroid lymphoma: report of two cases.

Primary thyroid lymphoma associated with Graves' disease.

Primary thyroid lymphomas.

Outcome analysis for stage IE and IIE thyroid lymphoma.

Malignant lymphoma of the thyroid gland: a clinicopathologic study of 108 cases.

Malignant lymphoma and other lymphoproliferative disorders of the thyroid gland. A clinicopathologic study of 245 cases.

Non-Hodgkin's lymphoma of the thyroid gland: prognostic factors and treatment outcome. The Princess Margaret Hospital Lymphoma Group.

Thyroid non-Hodgkin's lymphoma expression pattern of nuclear retinoid and rexinoid receptor subtypes.



Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)






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