Pathology of Medullary Carcinoma
of the Thyroid:
Undifferentiated, neuroendocrine tumor arising from the Parafollicular cells or C-cells of the Thyroid gland.
Dr Sampurna Roy MD April 2016
carcinoma is an undifferentiated, neuroendocrine tumor which arises from the
parafollicular cells or C-cells of the thyroid gland.
The particular characteristic of this tumor is the production of calcitonin 1 as well as ACTH, histaminase, corticotrophin, vasoactive intestinal peptide, serotonin, and carcinoembriogenic antigen (CEA).
Medullary thyroid carcinoma can be either sporadic (65–70%) or familial as part of the multiple endocrine neoplasia type 2 (MEN2) syndrome.
In most patients with a newly diagnosed MTC, a locoregional metastasis has already taken place, and a distant metastasis is present in 15–20% of patients.
The most common sites of metastasis presentation are the lungs, liver, and bones, and metastasis rarely occurs in the brain, skin, and breast.
Munoz Bendix C, Santacroce A, Gierga K, et al. Recurrent spinal metastasis of a sporadic medullary carcinoma of the thyroid after radiation therapy: a case report and review of the literature. Clinical Case Reports. 2016;4(1):9-18. doi:10.1002/ccr3.409.
Medullary carcinoma can appear in many different growth patterns.
The most common variant comprises small packets of short spindle cells with a readily recognizable "neuroendocrine" appearance.
It some rare cases papillary structures are present. Although papillae are present, these tumours are clearly not papillary carcinoma because the characteristic nuclear changes are absent.
The confirmation of medullary carcinoma rests on argyrophil stains, immunohistochemistry for calcitonin, calcitonin gene product, other neuroendocrine markers.
|Histopathology-India.net ; Dermatopathology Cases ; Pathopedia-India.com ; Pathology-India.com; Gallbladder Pathology Online ; Surgical Pathology.com ; Dermpath-India ; Infectious Disease Online ; Pathology Quiz Online ; Paediatric Pathology Online ; Pancreatic Pathology Online ; Paraganglioma-Online ; Endocrine Pathology Online ; Eye Pathology Online ; Ear Pathology Online ; Cardiac Path Online ; Pulmonary Pathology Online ; Lung Tumour Online ; Mesothelioma-Online ; Nutritional Pathology Online ; Environmental Pathology Online ; Soft Tissue Tumour Online-India ; GI Path Online-India ; Case Index ; E-book - History of Medicine with special reference to India; Microscope – Seeing the Unseen|
Copyright © 2016 histopathology-india.net