Pathology of Medullary Carcinoma

of the Thyroid

  Dr Sampurna Roy MD                                         January 2016

Medullary carcinoma can appear in many different growth patterns.

The most common variant comprises small packets of short spindle cells with a readily recognizable

"neuroendocrine" appearance.

It some rare cases papillary structures are present. Although papillae are present, these tumours are

clearly not papillary carcinoma because the characteristic nuclear changes are absent.

The confirmation of medullary carcinoma rests on argyrophil stains, immunohistochemistry for calcitonin,

calcitonin gene product, other  neuroendocrine markers, and, somewhat



Further reading

Diagnosis of medullary thyroid carcinoma by calcitonin measurement in fine-needle aspiration biopsy specimens.

Molecular characterization of the desmoplastic tumor stroma in medullary thyroid carcinoma.

Current approaches to medullary thyroid carcinoma, sporadic and familial.

Natural history, diagnosis, treatment and outcome of medullary thyroid cancer: 37 years experience on 157 patients.

Pseudoangiosarcomatous features in medullary thyroid carcinoma spindle-cell variant. Report of a case studied by FNA and immunohistochemistry.


Dr Sampurna Roy  MD

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