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Pathology of Trichinosis

Dr Sampurna Roy MD

 

                                                                                                                      

 

Syn: Trichinellosis ; Trichiniasis

 

Trichinosis, an infection by the nematode Trichinella spiralis, is most common in eastern and central Europe, North America, and Central and south America.

Visit: There is hidden danger lurking in your meat - Life cycle of Trichinella spiralis

 

Image Link1  ;  Image Link2.

Although it prevails in areas where pork is eaten, many animals, including dogs, cats, rats, bears, foxes, and  wolves, are reservoirs of infection.

Humans become infected by eating undercooked or raw meat containing encysted larvae, mainly pork.

The cysts located in striated muscle, are digested, liberating larvae that mature to adult worms that attach to the wall of the small intestine.

Female worms there liberate larvae that invade the  intestinal wall, enter the circulation, and penetrate striated muscle, where they encyst and remain viable for years.

The clinical features are highly variable, depending on the number of larvae ingested, and patients may be asymtomatic or die of a fulminating disease.

In subclinical disease the only sign is eosinophilia.

The invasion of muscle by the larvae is associated with muscle pain, swelling of the eyelids and facial edema, eosinophilia, and pronounced fever.

Respiratory and neurologic manifestatations may appear.

Fatal cases are usually attributed to a severe myocarditis.

During the chronic phase of the disease the symptoms gradually attenuate.

On invasion of the muscle the larvae cause inflammation and destruction of muscle fibres. A fibrous hyaline layer develops around a single coiled larva. Histiocytes and giant cells may surround the cyst, which eventually calcifies.    

The most frequently involved muscles are those of the limbs, diaphragm, tongue, jaw, larynx, ribs and eye.

Larvae in other organs, including the heart and brain, cause edema, necrosis, and focal infiltration of neutrophils, eosinophils, and lymphocytes, but they do not encyst.

The diagnosis is made by identifying larvae in muscle biopsies or by serologic tests.

Antihelminthic drugs remove adult worms from the intestine.

Further reading:

Characterization of TsDAF-21/HSP90 protein from the parasitic nematode Trichinella spiralis.

Indirect versus direct detection methods of Trichinella spp. infection in wild boar (Sus scrofa).

Trichinella species circulating in wild boar (Sus scrofa) populations in Poland.

Description of an outbreak of human trichinellosis in an area of Argentina historically regarded as Trichinella-free: the importance of surveillance studies.

Trichinella infection in wild boars and synanthropic rats in northwest Vietnam.

Searching for Trichinella: not all pigs are created equal.

The hidden burden of trichinellosis in Vietnam: a postoutbreak epidemiological study.

Protective immunity against Trichinella spiralis infection induced by a multi-epitope vaccine in a murine model.

Epidemiological study of recorded trichinosis cases in Santa Fe Province, Argentina, 1998-2009.

Trichinosis caused by ingestion of raw soft-shelled turtle meat in Korea.

Analysis of distribution and pathological characteristics of 9 fatal trichinosis cases in Yunnan.

Trichinellosis in Poland in 2011.

Trichinella infections in different host species of an endemic district of Serbia.

[The epidemiology of trichinosis on the Arctic shores of Chukotka during traditional nature management].

Immune response to a Trichinella spiralis infection in house mice from lines selectively bred for high voluntary wheel running.

Trichinellosis in mice: effect of albendazole on the glutathione transferase in the intestines.

Evaluation of recombinant serine protease inhibitor from Trichinella spiralis for immunodiagnosis of swine trichinosis.

 

 

Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)


 

 

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