Sebaceous Tumours

      

http://www.histopathology-india.net/SebTum.htm

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     Path Quiz Case 83 - Diagnosis:

                    Fordyce's Spots

         Ectopic Sebaceous Glands

      Dr  Sampurna Roy  MD

  Path Quiz Case 83: Case history and images:

 
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Ectopic sebaceous glands without attached hair follicle may be present near mucocutaneous junction. 

Clinical presentation:   The incidence of Fordyce's granules increases from childhood to adulthood, and is slightly higher in men. Presents as tiny yellow papules.  Dermatopathology Case

Site:  Fordyce's Spots - Present along vermillion border of the lips or on the oral mucosa.

Montgomery's tubercle-  Normal sebaceous glands are distributed along a circle in the periphery of the areola of the breast.

Ectopic sebaceous glands are occasionally found in other sites - 

Eg:  Esophagus;  penis;  labia minora ; vagina

Normal sebaceous glands on the vermilion border of the lips and the oral mucosa are common in adults. Only pathologic sebaceous glands visible through the epithelium should be regarded as Fordyce's granules.

Microscopic features:  Image Link1 ; Image Link2 ; Image Link3 ; Image Link4 .    

Histology shows a single sebaceous gland lesion consisting of single or a group of small but mature sebaceous lobules around small sebaceous duct extending to the surface epithelium. No associated hair follicles are seen.

Image

Differential diagnosis: Sebaceous hyperplasia (enlarged sebaceous glands with numerous lobules around a centrally located wide duct).

                     

Abstracts:

Sebaceous adenoma of oral cavity: report of case and comparative proliferation study with sebaceous gland hyperplasia and Fordyce's granules.Oral Dis 2003;9(6):323-7

Hyperplasia of sebaceous glands (Fordyce's disease) in an oral mucocutaneous graft: 45-year follow-up. Klin Monatsbl Augenheilkd. 1999;214(3):185-7.

Heterotopic sebaceous glands in the esophagus: histopathological and immunohistochemical study of a resected esophagus.Pathol Int. 1999 Apr;49(4):364-8.

Fordyce spots. A little regarded finding in the area of lip pigmentation and mouth mucosa. Laryngorhinootologie. 1995;74(6):390-2.

Areolar sebaceous hyperplasia with a Fordyce's spot-like lesion. J Dermatol. 1994 Jul;21(7):524-6.

Ectopic gingival sebaceous glands presenting as localized periodontitis. J Periodontol. 1990;61(1):58-60.

Fordyce's granules in the oral mucosa of adult Israeli Jews.Community Dent Oral Epidemiol. 1986 Aug;14(4):231-2.

Montgomery's areolar tubercle. A light microscopic study.Arch Pathol Lab Med. 1982;106(2):60-3.

Fordyce's spots: disease, heterotopia or adenoma? Histological and ultrastructural study. J Biol Buccale. 1981 ; 9(2):109-28.  

Fordyce's condition of the buccal mucosa and perimamillary region. Hautarzt. 1971 Jun;22(6):263-4.

 

                      

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February  2010

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