Site created by

    Dr Sampurna Roy MD

http://www.histopathology-india.net/dermpath.htm

Cysts:

Hydrocystoma -Eccrine/Apocrine

Hamartomas:

Eccrine/Apocrine naevus

Eccrine Angiomatous Hamartoma

Porokeratotic eccrine ostial naevus

Benign Neoplasms:

Syringocystadenoma Papilliferum

Hidradenoma Papilliferum

Nipple Adenoma

Syringoma

Spiradenoma

Cylindroma

Chondroid Syringoma (benign mixed tumour)

Poroma

Hidradenoma

Apocrine adenoma

Papillary eccrine adenoma

Syringofibroadenoma

Hidradenocarcinoma is a rare sweat gland tumour.

The tumour range from locally recurring , low grade well differentiated tumour to highly aggressive high grade tumour with potential for local and distant metastasis to lymphnodes, bones and lungs.

Site:  Often located on the face, scalp and extremities as an ulcerated reddish nodules.

Age: In elderly patients and sometimes in children and at birth.

Microscopic features: 

    Case Link1:  Case Link2

Asymmetrical tumour ;  Infiltrative dermal proliferation of variable sized lobules and nests showing cyst formation ; Connection to the epidermis is rare ; Composed of a mixture of eosinophilic polygonal cells, squamous cells, mucinous and clear cells;  Pleomorphism and necrosis is common;  There are ducts and intracytoplasmic lumina; Decapitation secretion is present in some cases ; Glycogen is demonstrated in the cytoplasm of some of the clear cells.

Differential diagnosis:  Clear cell carcinoma of the skin:click

Tumours composed predominantly of clear cells need to be distinguished from metastatic clear cell carcinoma particularly renal cell carcinoma.

Abstracts:

Skin adnexal neoplasms--part 2: An approach to tumours of cutaneous sweat glands.J Clin Pathol. 2007 Feb;60(2):145-59. Epub 2006 Aug 1.

Nodular hidradenocarcinoma on the scalp of a young woman: case report and review of literature.Dermatol Surg. 2004 ;30(9) :1265-8.

Malignant eccrine hidradenoma of neck causing acute heart failure.Auris Nasus Larynx. 2003;30(3):307-10.

Nodular hidradenocarcinoma with prominent squamous differentiation: case report and immunohistochemical study.J Cutan Pathol. 2000;27(8):423-7.

Giant hidradenocarcinoma: a report of malignant transformation from nodular hidradenoma.Pathol Int. 1998 ;48(10):818-23.

Metastatic clear cell eccrine hidradenocarcinoma of the vulva: survival after primary surgical resection.Gynecol Oncol. 1996 ;61(2):287-90.

Malignant clear cell hidradenoma of the upper lip.Head Neck. 1994;16(5) :443-9.

Nodular hidradenoma and hidradenocarcinoma. A 10-year review.J Am Acad Dermatol. 1985 ;12(1 Pt 1):15-20.

Vulvar sweat gland carcinomas. Arch Pathol Lab Med. 1985 ;109(1):43-7.

Clear cell hidradenocarcinoma- a case report with unusual in situ malignant changes.J Surg Oncol. 1984;26(1):1-5