Custom Search

       

Dermpath-India

Pathology of Hidradenocarcinoma

Dr Sampurna Roy MD                

 

                                                                                                                      

 

 

Hidradenocarcinoma is a very rare sweat gland tumour.

The tumour range from locally recurring, low grade well differentiated tumour to highly aggressive high grade tumour with potential for local and distant metastasis to lymphnodes, bones and lungs.

Site: Often located on the face, scalp and extremities as an ulcerated reddish nodules.

Age: In elderly patients and sometimes in children and at birth.

 
Microscopic features: 

Diagram showing the features:

Hidradenocarcinoma is a very rare tumour. 

Characteristic features are as follows:

Asymmetrical tumour ;  Infiltrative dermal proliferation of variable sized lobules and nests showing cyst formation ;

Connection to the epidermis is rare ;

Composed of a mixture of eosinophilic polygonal cells, squamous cells, mucinous and clear cells; 

Pleomorphism and necrosis is common; 

There are ducts and intracytoplasmic lumina;

Decapitation secretion is present in some cases ; Glycogen is demonstrated in the cytoplasm of some of the clear cells.

 


Criteria of malignancy :

-Infiltrative growth pattern.

-Prominent cytological atypia. In some cases there is minimal atypia.

-High mitotic activity (not reliable criteria)

-Perineural invasion

-Vascular invasion

-Presence of comedonecrosis.

 

Differential diagnosis:  Clear cell carcinoma of the skin

Tumours composed of predominantly clear cells. Hidradenocarcinoma needs to be distinguished from metastatic clear cell carcinoma particularly renal cell carcinoma.

 

Further reading:

Case Links:  Case Link1  ;  Case Link2 Case Link3

Clear cell hidradenocarcinoma mimicking pyogenic granuloma after repeated surgical excision.

Hidradenocarcinoma showing prominent mucinous and squamous differentiation and associated pagetoid cells.

Diagnosis and treatment of clear cell hidradenocarcinoma of the scalp.

Clear cell hidradenocarcinoma of the eyelid: a case report with a review of the literature.

Clear cell hidradenocarcinoma with helpful immunohistochemistry: a case report.

Cutaneous hidradenocarcinoma: a clinicopathological, immunohistochemical, and molecular biologic study of 14 cases, including Her2/neu gene expression/amplification, TP53 gene mutation analysis, and t(11;19) translocation.

Apocrine hidradenocarcinoma of the scalp: a classification conundrum.

Hidradenomas and a hidradenocarcinoma of the scalp managed using Mohs micrographic surgery and a multidisciplinary approach: case reports and review of the literature.

Clear cell hidradenocarcinoma developing in pacemaker pocket.

Hidradenocarcinoma: a histological and immunohistochemical study.

Skin adnexal neoplasms--part 2: An approach to tumours of cutaneous sweat glands.

Nodular hidradenoma and hidradenocarcinoma. A 10-year review.

Vulvar sweat gland carcinomas.

 

 

 

Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)

 


 

 

Histopathology-India.net

 

Pathopedia-India.com

 

Surgical Pathology.com

 

Pathology-India.com

 

Dermpath-India

 

Infectious Disease Online

 

Pathology Quiz Online 

 

Paediatric Pathology Online

 

Pancreatic Pathology Online

 

Paraganglioma-Online

 

Endocrine Pathology Online

 

Eye Pathology Online

 

Ear Pathology Online

 

Cardiac Path Online

 

Pulmonary Pathology Online

 

Lung Tumour Online

 

Mesothelioma-Online

 

Nutritional Pathology Online

 

Environmental Pathology Online

 

Soft Tissue Tumour Online

 

GI Path Online-India

 

Gallbladder Pathology Online

 

E-book - History of Medicine  

 

Microscope - Seeing the Unseen

 

 roypath.in

 

Disclaimer

Privacy Policy  

Advertising Policy

Copyright 2017  histopathology-india.net