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Vascular Tumours
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Microvenular Hemangioma
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Epithelioid hemangioma (angiolymphoid hyperplasia with eosinophilia) Lobular capillary hemangioma (pyogenic granuloma Acro-angiodermatitis / pseudo-Kaposi's sarcoma Reactive angioendotheliomatosis Targetoid hemosiderotic hemangioma(Hobnail hemangioma) Spindle cell hemangioma / hemangioendothelioma Kaposiform hemangioendothelioma Papillary intralymphatic angioendothelioma (Dabska's tumour) Epithelioid hemangioendothelioma Dermatofibroma (aneurysmal variant) |
Microvenular hemangioma is a rare, slowly growing, benign vascular tumour.
Clinical presentation: It usually presents as a solitary, asymptomatic, purple to red papule or plaque.
Age: Young to middle-aged adults.
Site: Extremities, particularly the forearms.
Microscopic features: Dermatopathology Case101
IMAGE LINKS : Images
Histologically, these tumours are characterized by a proliferation of small-sized, irregularly branched venules with inconspicuous lumina.
The tumour has an infiltrative growth throughout the dermis The backround stroma is desmoplastic.
The flattened endothelial cells have oval to spindle-shaped nuclei and scant cytoplasm. The endothelial cells are surrounded by pericytes.
The tumour cells lack cellular atypia, pleomorphism, and mitotic figures.
Immunohistochemistry: Endothelial cells: FactorVIII- related antigen and CD34 positive. Pericytes: Smooth muscle actin positive.
Differential diagnosis: Early onset Kaposi's sarcoma- Eosinophilic globules are not present in microvenular hemangioma.
In the context of the histological similarity to a low-grade malignant tumour - early onset Kaposi's sarcoma, the awareness of microvenular hemangioma, a benign vascular tumour, is important.
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Abstracts: Eruptive microvenular hemangiomas in 4 Chinese patients: clinicopathologic correlation and review of the literature.Am J Dermatopathol. 2010 Dec;32(8):837-40. Lack of expression of podoplanin by microvenular hemangioma.Pathol Res Pract. 2008;204(11):817-21 Microvenular hemangioma.Ann Dermatol Venereol. 2004 ;131(5):475-7. Microvenular hemangioma in a boy with acute myelogenous leukemia.Pediatr Dermatol. 2003;20(3):266-7. Microvenular hemangioma.Dermatology. 2003;206(2):161-4. Microvenular hemangioma.Pathol Int. 1998;48(3):237-9. Microvenular hemangioma.Am J Dermatopathol. 1993 ;15(6) :534-8. Microvenular hemangioma.J Cutan Pathol. 1991;18(4):235-40.
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