Dr Sampurna Roy MD May 2016
Spiradenoma is a benign dermal tumour
occuring in adults.
This lesion often coexists with cylindromas.
Usually presents as a painful or tender solitary nodule (less than 1cm in diameter).
May occasionally present as multiple lesions .
Giant variants, linear or zosteriform distribution have also been reported.
Site: Head and neck, sometimes on the scalp and on the trunk. Rarely on the extremities.
Malignant transformation of spiradenoma (Spiradenocarcinoma) may occur in rare cases.
Brooke-Spiegler syndrome is a rare, autosomally dominant disease characterized by the development of multiple cylindromas, trichoepitheliomas, and occasional spiradenomas.
Eccrine spiradenoma: co-expression of cytokeratin and smooth muscle actin suggesting differentiation toward myoepithelial cells.
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