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Steatocystoma presents as a solitary lesion (steatocystoma simplex) or multiple lesions  (steatocystoma multiplex) in adolescence or young adults.  

Steatocystoma multiplex is a rare benign autosomal dominant disorder of the pilosebaceous unit.  Mutations in keratin 17 have been found in some cases.

Site:   These lesions can appear virtually anywhere on the body but are more common in areas where the pilo-sebaceous apparatus is well developed, such as the trunk (especially the presternal area), neck, axilla, inguinal region, scalp, and proximal extremities.

Gross:
Macroscopically these are small, smooth, fleshy, cystic nodule.    DermAtlas: ;

Microscopic features:    ;  

Microscopically the lesion is located in the mid dermis . The cyst has a wavy wall, lined by squamous epithelium with a corrugated eosinophilic cuticle surface. No granular layer is usually seen. Flattened lobules of sebaceous glands are usually located in the wall. The cystic space contains, keratin, vellous hair, sebum etc.Each cyst is attached to overlying normal epidermis by thin strands of undifferentiated epithelial cells.

Differential diagnosis :  Eruptive vellous hair cyst, dermoid cyst, cystic sebaceous hyperplasia.

Abstracts:

Localized forms of steatocystoma multiplex: Case report and review of the literature.Dermatology Online Journal 2005;11(1): 22

Steatocystoma multiplex.Dermatol Online J. 2003;9(4):18.

Clinical and histologic features of 64 cases of steatocystoma multiplex.J Dermatol. 2002;29(3):152-6.

Late onset vulvar steatocystoma multiplex. Clin Exp Dermatol. 2002;27(6):445-7.

Acral steatocystoma multiplex.J Am Acad Dermatol. 2000 Aug;43(2 Pt 2):396-9

Congenital linear steatocystoma multiplex of the nose. Pediatr Dermatol. 2000;17(2):136-8

Persistent milia, steatocystoma multiplex and eruptive vellus hair cysts: variable expression of multiple pilosebaceous cysts within an affected family.Dermatology. 1998;196(4):392-6.

Steatocystoma multiplex: a case with unusual clinical and histological manifestation.Am J Dermatopathol. 1997 ;19(1):89-92.

Eruptive vellus hair cyst and steatocystoma multiplex: two related conditions?J Cutan Pathol. 1988;15(1):40-2.

Steatocystoma multiplex. A facial papular variant.Arch Dermatol. 1986 Feb;122(2):205-7.

Steatocystoma multiplex: anatomic reevaluation, electron microscopy, and autoradiography.Arch Dermatol Res. 1982;272(3-4):363-80.

Steatocystoma simplex. A solitary steatocystoma.Arch Dermatol. 1982 Jun;118(6):409-11.

Sebaceous tumours: Fordyce's Spots ; Steatocystoma ; Nevus Sebaceous ;Folliculosebaceous Cystic Hamartoma; Sebaceous Hyperplasia  ; Sebaceoma ; Sebaceous Adenoma;Sebaceous Carcinoma;

Soft Tissue Pathology: Myxoid Tumours of Soft Tissue ;  Classification of Soft Tissue Tumour;  Gross examination of soft tissue specimen ;  A practical approach to histopathological reporting of soft tissue tumours ;  Grading of soft tissue tumours ; Lipomatous tumours ;Neural tumours ; Myogenic tumours ;Vascular tumours Fibroblastic/Myofibroblastic tumours ; Myofibroblastic tumours ;  Fibrohistiocytic tumours ; ChondroOsseous tumours ; Soft TissueTumours of Uncertain Differentiation ; Notochordal Tumour -Chordoma ;Extra-adrenal Paraganglioma ; Gastrointestinal Stromal Tumour ;