Pathology of Verrucous
Dr Sampurna Roy MD June 2016
|Syn: Verrucous Venous
Verrucous hemangioma is a vascular malformation characterized by vascular spaces in the dermis and subcutaneous tissue with overlying hyperkeratotic, papillomatous epidermis.
Age: Arise at birth or childhood.
Site: Occurs predominantly on the legs.
Presents as blue-red, vascular papules, plaques or nodules, which later becomes warty in appearance.
Small satellite nodules may be present.
These lesions do not resolve spontaneously and have a tendency to recur after excision if margins are inadequate.
Couto JA, Vivero MP, Kozakewich HPW, et al. A Somatic MAP3K3 Mutation Is Associated with Verrucous Venous Malformation. American Journal of Human Genetics. 2015;96(3):480-486. doi:10.1016/j.ajhg.2015.01.007.
Histopathologic examination shows irregular papillomatosis, acanthosis and hyperkeratosis of the epidermis.
The superficial dermis shows multiple, thin-walled, dilated blood-filled spaces.
Similar spaces are present in the lower dermis and subcutaneous tissue.
Angiokeratoma: Only the superficial blood vessels are dilated.
In verrucous hemangioma the vascular spaces are present in the dermis and subcutaneous tissue.
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