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Pathology of Marburg Virus Disease

Dr Sampurna Roy MD

                                                                                                                      

 

 

Syn: Green-monkey-disease

 

Marburg virus disease, a severe, distinctive, hemorrhagic illness with a high rate of mortality, is heralded early by severe sore throat, a maculopapular rash, and a red exanthem on the hard and soft palate.

Later, severe, generalized bleeding dominates the clinical course.

The disease was first recognized in 1967 in Marburg, Germany, and Belgrade  in the former Yugoslavia, among laboratory workers exposed to blood and tissues from African green monkeys imported from Uganda.

There have been subsequent outbreaks in South Africa, Kenya, and Zimbabwe.

The Marburg and Ebola viruses are interpreted as the first recognized viruses of the family, the Filoviridae.

Marburg hemorrhagic fever has affected many fewer persons than Ebola virus. Thus, the recent large outbreak that was declared over in November 2005 is of particular interest, especially since before this outbreak, cases in children were rare, and in this outbreak, children account for a high proportion of those affected.

Transmission of these viruses occurs by direct contact with infected body fluids from animals and humans, such as blood, saliva, vomitus, respiratory droplets, urine and stool, and contact with virus-contaminated objects (e.g.  needles, syringes).

Persons who prepare, cook, and eat contaminated animals may become infected.

Person-to-person transmission occurs, as does infection from direct inoculation. Transmission via semen may occur weeks after recovery.

It is extremely important to use proper barrier nursing techniques to prevent secondary cases of Ebola and Marburg virus hemorrhagic fevers to caretakers and families, including use of standard, contact, and airborne isolation precautions.

There is also concern about use of the filoviruses as bioterror agents, especially if the viruses could be modified to efficiently spread via aerosol from person-to-person.

Visit: Ebola Virus Disease ; Lassa Fever.

 

Further reading:

Cross-protection against Marburg virus strains by using a live, attenuated recombinant vaccine.

Geographic potential for outbreaks of Marburg hemorrhagic fever.

Emerging infectious diseases at the beginning of the 21st century.

Marburg hemorrhagic fever--the forgotten cousin strikes.

Outbreak of Marburg hemorrhagic fever in Angola: a review of the history of the disease and its biological aspects.

 


 

 

Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)

 

 


 

 

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