Pathology of Angiomyofibroblastoma -Infographic
Angiomyofibroblastoma is a rare myofibroblastic tumour of superficial soft tissues described by Fletcher et al. in 1992.
Age: Usually occurs in young to middle aged females in their reproductive years (25 to 50 years).
Rare cases occur in males with the age ranging from 40 to 80yrs.
Occurs in the vulvovaginal region of women. Rare cases have been reported in the female urethra and fallopian tube.
Clinically the lesion may be mistaken for Bartholin's cyst or inguinal hernia.
In males, the tumour may occur in the scrotum or paratesticular tissues.
Clinically, the lesion may present as a scrotal mass, hernia or hydrocele.
The tumours are mostly well circumscribed, round, ovoid, or lobulated masses with a soft to rubbery consistency measuring 0.5-12 cm in maximum dimension.
The cut surface has a greyish-brown homogeneous appearance with no hemorrhage or necrosis.
In some cases the tumour may present as a gelatinous mass which is completely encapsulated by a thin fibrous capsule.
The stromal cells are consistently positive for vimentin and desmin (strongly and diffusely).
Muscle specific actin - negative or weakly positive. Alpha-smooth muscle actin - focally positive or negative.
Myosin, cytokeratins, S-100 protein and von Willebrand factor are negative
Both estrogen and progesterone (some cases) receptors may be diffusely expressed in the tumour, suggestive of the sex steroid-dependency of this tumour.
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