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Pathology of Hidradenoma


(Papillary Hidradenoma)

Dr Sampurna Roy MD

Path Quiz Case 26- Case history and images:

Diagnosis: Hidradenoma Papilliferum


Hidradenoma papilliferum (papillary hidradenoma) is a benign tumour and was previously regarded as an apocrine tumour.

According to some authors this tumour is a variant of apocrine adenoma with specific features.

Now there is increasing evidence to suggest that it is closely related to the recently described mammary-like anogenital glands. 

Site:  Almost always located in the vulval or perianal regions. Ectopic lesions have been reported on the face, scalp, eyelid, auditory canal and arm.

Clinical presentation: The tumour usually occurs in middle aged women as small nodules (1cm or less in size).

Microscopic features:

Histologically, these are circumscribed solid or partly cystic tumour containing papillary and glandular areas.

There are two types of epithelium -  tall columnar cells with pale eosinophilic cytoplasm and underlying myoepithelial cell layer.

Prominent apocrine changes are noted in areas. 

Mitotic count is occasionally high.

PAS- positive diastase-resistant granules are present in the apices of the large cells.


Differential Diagnosis:  

The differential diagnosis includes adenocarcinoma.


Further reading:

Hidradenoma papilliferum occurring on the nasal skin.

Hidradenoma papilliferum of the vulva: case report and review of literature.

Diagnosis of hidradenoma papilliferum of the vulva on cytologic smears: a case report.

Ectopic hidradenoma papilliferum.

Hidradenoma papilliferum with mixed histopathologic features of syringocystadenoma papilliferum and anogenital mammary-like glands: report of a case and review of the literature.

Pseudocarcinomatous hyperplasia associated with hidradenoma papilliferum.

A giant ectopic hidradenoma papilliferum in a Niger delta region of Nigeria.

Hidradenoma papilliferum presenting as an eyelid mass.



Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)







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