This
benign tumour was previously regarded as an apocrine tumour . According to
some authors this tumour is a variant of apocrine adenoma with specific
features. Now there is
increasing evidence to suggest that it is closely related to the
recently described mammary-like anogenital glands.
Site:
Almost always located in the vulval or perianal regions. Ectopic lesions
have been reported on the face, scalp, eyelid, auditory canal and arm.
Clinical presentation:
The tumour usually occurs in middle aged women as small nodules (1cm or less
in size).
Microscopic features:
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Histologically, these are circumscribed solid or partly cystic tumour
containing papillary and glandular areas.
There are two types of epithelium
- tall columnar cells with pale eosinophilic cytoplasm and underlying
myoepithelial cell layer. Prominent apocrine changes are noted in areas.
Mitotic count is occasionally high.
PAS positive
diastase-resistant granules are present in the apices of the large
cells.
The differential diagnosis includes adenocarcinoma. |