Custom Search




Pathology of Hidradenoma

Papilliferum (Papillary Hidradenoma)

Dr Sampurna Roy MD


Path Quiz Case 26- Case history and images:

Diagnosis: Hidradenoma Papilliferum





Hidradenoma papilliferum (papillary hidradenoma) is a benign tumour and was previously regarded as an apocrine tumour.

According to some authors this tumour is a variant of apocrine adenoma with specific features.

Now there is increasing evidence to suggest that it is closely related to the recently described mammary-like anogenital glands. 

Site:  Almost always located in the vulval or perianal regions. Ectopic lesions have been reported on the face, scalp, eyelid, auditory canal and arm.

Clinical presentation: The tumour usually occurs in middle aged women as small nodules (1cm or less in size).

Microscopic features:

Histologically, these are circumscribed solid or partly cystic tumour containing papillary and glandular areas.

There are two types of epithelium -  tall columnar cells with pale eosinophilic cytoplasm and underlying myoepithelial cell layer.

Prominent apocrine changes are noted in areas. 

Mitotic count is occasionally high.

PAS- positive diastase-resistant granules are present in the apices of the large cells.


Differential Diagnosis:  

The differential diagnosis includes adenocarcinoma.


Further reading:

Hidradenoma papilliferum occurring on the nasal skin.

Hidradenoma papilliferum of the vulva: case report and review of literature.

Diagnosis of hidradenoma papilliferum of the vulva on cytologic smears: a case report.

Ectopic hidradenoma papilliferum.

Hidradenoma papilliferum with mixed histopathologic features of syringocystadenoma papilliferum and anogenital mammary-like glands: report of a case and review of the literature.

Pseudocarcinomatous hyperplasia associated with hidradenoma papilliferum.

A giant ectopic hidradenoma papilliferum in a Niger delta region of Nigeria.

Hidradenoma papilliferum presenting as an eyelid mass.



Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)






Infectious Disease Online


Pathology Quiz Online 


Paediatric Pathology Online


Pancreatic Pathology Online




Endocrine Pathology Online


Eye Pathology Online


Ear Pathology Online


Cardiac Path Online


Pulmonary Pathology Online


Lung Tumour Online




Nutritional Pathology Online


Environmental Pathology Online


Soft Tissue Tumour Online


GI Path Online-India


Gallbladder Pathology Online


E-book - History of Medicine  


Microscope - Seeing the Unseen




Privacy Policy  

Advertising Policy

Copyright 2019