Syn: Naevus
Sebaceus of Jadassohn ; Organoid Naevus
Nevus sebaceus of Jadassohn is a benign, congenital hamartoma of the folliculo-sebaceous apocrine
unit and epidermis that often presents at birth, appears to regress in
childhood, and grows during puberty, suggesting possible hormonal
control.
Clinical presentation:
In childhood, the lesion consists of a circumscribed hairless
yellow-orange-colored, waxy, pebble-like, papule or plaque often
linear or round or irregular. In puberty the lesion becomes verrucous and nodular.
Site:
Located on the scalp, face
or neck as a solitary lesion & usually present since birth.
Nevus sebaceous may develop tumours in adulthood particularly,
syringocystadenoma papilliferum
and
benign hair follicle tumours. Basal cell carcinoma has been observed in about 5
percent cases.
Microscopic features:
Image
Links(Dr
Weems):


Histologically, there is verrucous epidermal hyperplasia together with
immature sebaceous
gland and basaloid hyperplasia. Immature hair structures and dilated
infundibulum are present. Ectopic apocrine glands are also noted.
The sebaceous glands are well developed in the first few months of life,
through childhood
sebaceous glands are underdeveloped and in adolescence these are reduced in number and size.
Differential diagnosis:
Sebaceous hyperplasia ;
Seborrheic keratosis.
It may be difficult to differentiate between basal cell carcinoma and
basaloid proliferation that arise in malformed hair germs in nevus
sebaceous. |