Custom Search



Neural Tumours

Pathology of Solitary Circumcribed Neuroma (Palisaded Encapsulated Neuroma)

Dr Sampurna Roy MD            

Path Quiz Case 63: Case history and images:

Diagnosis: Solitary Circumcribed Neuroma

(Palisaded Encapsulated Neuroma)




Solitary, circumscribed neuroma is a distinctive benign cutaneous tumour that was first described under the name "palisaded encapsulated neuroma" in 1972 by Reed and colleagues.

(Arch Dermatol. 1972 Dec;106(6):865-70 ).

These are slow growing lesions and are usually present on the face or close to a mucocutaneous junction in middle-aged adults.

It is rarely found in other locations, such as the glans penis, oral mucosa, neck, shoulders, upper part of the arms.

Clinically, they are often diagnosed as basal cell carcinoma, melanocytic naevus, epidermal cyst or skin appendage tumours.

Macroscopically these are usually firm sessile well circumscribed intradermal nodules measuring between 2 mm to 6 mm in diameter.

Histologically, solitary circumscribed neuromas are well-circumscribed dermal tumours composed of a partially encapsulated mass of bland Schwann cells and innumerable tiny axons arranged in interlacing fascicles.

A fibrous capsule composed of flattened, elongated perineural cells is present around the nodule.

No pleomorphism is seen and mitotic figures are rarely present.

Occasional small blood vessels are seen in the stroma but haemorrhage and necrosis have not been reported.

Variants: Nodular: Most common. Other rare variants: epithelioid ; plexiform ; multinodular ; increased vasculature ; fungating growth pattern.

Immunohistochemistry :  Interlacing fascicles of Schwann cells are S-100 protein positive.

Numerous tiny axons are neurofilament positive. The capsule is composed of perineural cells that show epithelial membrane antigen positivity.  

Differential diagnosis: 

1. Neurofibroma: ( Neurofibroma lacks capsule and contains fewer axons with myelin sheaths.

Mucopolysaccharide ground substance is present.

May be associated with von-Recklinghausen's disease).

2. Schwannoma: (Schwannoma lacks axons, contains Antoni A and Antonic B areas and Verocay bodies.

Usually present in a subcutaneous location.

3. Traumatic neuroma:  (Scarring and inflammatory cells are present together with Schwann cells and axons).   

4. Leiomyoma:  (Spindle cell lesion composed of muscle cells).

Solitary circumscribed neuroma is a benign lesion probably caused by primary hyperplasia of the nerve fibres.  

Even after incomplete excision the lesion does not recur.  

An association with neurofibromatosis or MEN syndrome type IIb has never been found.

Further reading:

Palisaded encapsulated neuroma--a classic presentation of a commonly misdiagnosed neural tumor. 

Solitary circumscribed neuroma (palisaded encapsulated neuroma) of the oral mucosa].

Palisaded encapsulated neuroma (solitary circumscribed neuroma of skin) of the eyelid: report of two cases and review of the literature. 

Neural spectrum: palisaded encapsulated neuroma and verocay body poor dermal schwannoma. 

Palisaded encapsulated neuroma (solitary circumscribed neuroma) of the oral mucosa.

Palisaded encapsulated neuroma (solitary circumscribed neuroma). A clinicopathologic and immunohistochemical study. 

Plexiform and other unusual variants of palisaded encapsulated neuroma. 

Immunohistochemical characterization of palisaded, encapsulated neuroma.

Encapsulated neuroma of the skin. A clinical, histologic and immunohistologic study

Palisaded encapsulated neuromas. A clinicopathologic study.

Palisaded encapsulated neuroma: an immunohistochemical study.

Solitary circumscribed neuroma of the skin (so-called palisaded, encapsulated neuroma). A clinicopathologic and immunohistochemical study.



Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)






Infectious Disease Online


Pathology Quiz Online 


Paediatric Pathology Online


Pancreatic Pathology Online




Endocrine Pathology Online


Eye Pathology Online


Ear Pathology Online


Cardiac Path Online


Pulmonary Pathology Online


Lung Tumour Online




Nutritional Pathology Online


Environmental Pathology Online


Soft Tissue Tumour Online


GI Path Online-India


Gallbladder Pathology Online


E-book - History of Medicine  


Microscope - Seeing the Unseen





Privacy Policy  

Advertising Policy

Copyright 2019