Custom Search



Pathology of Syringoma

Dr Sampurna Roy MD   




Syringoma is a benign adnexal tumour. The name syringoma is derived from the Greek word syrinx, which means pipe or tube.

Pinterest1 ; Pinterest2

These lesions are common in patients with Down syndrome.

Clear cell syringoma are commonly associated with diabetes mellitus.

Dermatopathology patterns that remind us of something else

Clinical presentation:

i) Multiple papules on the lower eyelids and cheeks of adolescent females

ii) Solitary and giant lesions, plaque form or milia-like lesions limited to the vulva, penis, buttock, neck, scalp, axilla, abdomen or extremities.

Eruptive syringoma is a rare, clinically distinct variant of syringoma. 

Microscopic features: 


Dermal tumours are composed of small ducts lined by two layers of cuboidal epithelium ;

Ducts have a comma-like tail (tadpole appearance);

Solid nests and strands of basaloid cells may be present in the dermis ;

Some ducts contain eosinophilic material ;

Backround stroma is usually fibrotic ;

The lesion is well demarcated from the surrounding dermis ;

Numerous mast cells are present in the stroma in some cases;

Clear cell variant- ducts are lined by epithelial cells with pale or clear cytoplasm.


Tumour cells express cytokeratin10  in the intermediate cells, cytokeratin 6 and 19 and Carcinoembryonic antigen (CEA) in the luminal cells and epithelial membrane antigen (EMA) in the peripheral cells of the duct.  

(Differential diagnosis - Carcinoembryonic antigen (CEA) is negative in desmoplastic trichoepithelioma ).  

Progesterone receptors are expressed in most syringomas.

Differential diagnosis:   

Microcystic adnexal carcinoma (no perineural invasion or deep extension in syringoma).  It is impossible to make the distinction in a shave biopsy.

Chondroid syringoma.


Further reading:

An unusual presentation and distribution of generalized eruptive syringomas.

Multiple giant vulvar syringoma: an extraordinary report.

Vulvar nonclear cell syringoma associated with pruritus and diabetes mellitus.

Cutaneous syringoma: a clinicopathologic study of 34 new cases and review of the literature.

Penile syringoma: reports and review of patients with syringoma located on the penis.

Linearly distributed syringoma: a case report.

"Eruptive" facial syringomas: an inflammatory skin reaction?


Top 10 Facts about Littoral Cell Angioma of the Spleen

8 things you should know about Pathology of Chondroblastoma ;

7 Quick Facts about Sclerosing Polycystic Adenosis ;

Did you know these 11 fascinating facts about Myelolipoma? ;

10 Basic Facts that you should know about Epithelial Myoepithelial Carcinoma of the Salivary Gland ;

8 Pathology Facts - Sclerosing Rhabdomyosarcoma;

12 Pathology Facts - Angiomatoid Fibrous Histiocytoma; 

What is Fibroepithelioma of Pinkus ?

Gastric Kaposi's Sarcoma- Interesting Facts that you should know





Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)







Infectious Disease Online


Pathology Quiz Online 


Paediatric Pathology Online


Pancreatic Pathology Online




Endocrine Pathology Online


Eye Pathology Online


Ear Pathology Online


Cardiac Path Online


Pulmonary Pathology Online


Lung Tumour Online




Nutritional Pathology Online


Environmental Pathology Online


Soft Tissue Tumour Online


GI Path Online-India


Gallbladder Pathology Online


E-book - History of Medicine  


Microscope - Seeing the Unseen





Privacy Policy  

Advertising Policy

Copyright 2017