Gastric Pathology

      

 http://www.histopathology-india.net/LipomatousTumours.htm

                                           HISTOPATHOLOGY INDIA.COM

                            HIBERNOMA

            Dr Sampurna Roy MD

 
Web www.histopathology-india.net
 May 2007 
Surgical-Pathology.com

Histopathology-India.net

Eye Pathology Online

Cardiac Path Online;

Pulmonary Pathology Online

Pathology Quiz Online;

Dermpath-India;

GI Path Online

Mesothelioma-Online;

Soft Tissue Pathology;

Infectious Disease Online; INDEX: A-D ; INDEX: E-L ; INDEX: M-P INDEX: Q-Z ; FUNGAL DISEASE ; VIRAL DISEASE.

Lipoma and variants

Lipoblastoma

Angiolipoma

Extrarenal Angiomyolipoma

Chondroid lipoma

Spindle cell/pleomorphic lipoma

Well differentiated Liposarcoma

De-differentiated liposarcoma 

Myxoid liposarcoma 

Round  cell liposarcoma

Pleomorphic liposarcoma 

                        

Lipofibromatosis is a rare pediatric lesion composed of abundant adipose tissue together with bundles of fibroblasts.

According to Fetsch et al - [ this tumour comprises part of the spectrum of what has been referred to in the literature as infantile/juvenile fibromatosis, its clinicopathologic features and, in particular, its distinctive tendency to contain fat as an integral component, warrant separate classification as a "lipofibromatosis."]
 

Age: 11 days to 12 years

Site:  The patients usually  presented with a soft tissue mass  involving upper and lower extremities, trunk , head or neck.

Microscopic features:

Two components:1.Bundles of spindle shaped fibroblast-like cells with focal fascicular pattern 2. Disorganized mature adipose tissue.The lesion mainly involved the septa of fat and skeletal muscle. Mitotic activity is limited  - Less than I/10HPF. Cytological atypia is not prominent.  The tumours entrapped vessels, nerves, skin adnexa and skeletal muscle.

Immunohistochemistry:  CD99 ; smooth muscle actin ; bcl2 - Focal Positivity  , S100 protein ; muscle actin ; EMA  - Less frequently positiveDesmin ; Keratins ; CD57 - Negative

Differential diagnosis:  

-Fibromatosis;

-Fibrous hamartoma of infancy: In lipofibromatosis primitive nodular fibromyxoid component is absent. 

-Calcifying aponeurotic fibroma ; -Lipoblastoma

                       

 
Web www.histopathology-india.net
Abstracts:

A clinicopathologic study of 45 pediatric soft tissue tumors with an admixture of adipose tissue and fibroblastic elements, and a proposal for classification as lipofibromatosis.Am J Surg Pathol. 2000 ;24(11):1491-500.

Lipofibromatosis presenting as a pediatric neck mass.Int J Pediatr Otorhinolaryngol. 2004 Dec;68(12):1545-9

Infantile lipofibromatosis of the upper limb.Skeletal Radiol. 2005 Aug 11.

 
Soft Tissue Pathology;

Myxoid Tumours of Soft Tissue Classification of Soft Tissue Tumour;  Gross examination of soft tissue specimen ; A practical approach to histopathological reporting of soft tissue tumours Grading of soft tissue tumours ; Lipomatous tumours ; Neural tumours ; Myogenic tumours ;Vascular tumours ; Fibroblastic/ Myofibroblastic tumours ; Myofibroblastic tumours ;  Fibrohistiocytic tumours ; ChondroOsseous tumours ; Soft TissueTumours of Uncertain Differentiation ; Notochordal Tumour -Chordoma ;Extra-adrenal Paraganglioma ; Gastrointestinal Stromal Tumour ;