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        Dr  Sampurna Roy  MD

 
 
  Gastrointestinal Stromal Tumour

          

http://www.histopathology-india.net/Infection.htm

               

Lymphocytic choriomeningitis, or LCM, is a rodent-borne viral infectious disease that presents as aseptic meningitis (inflammation of the membrane, or meninges, that surrounds the brain and spinal cord), encephalitis (inflammation of the brain), or meningoencephalitis (inflammation of both the brain and meninges).

Its causative agent is the lymphocytic choriomeningitis virus (LCMV), a member of the family Arenaviridae that was initially isolated in 1933.

Lymphocytic choriomeningitis (LCM) virus infection is probably widespread through the world, though it has been rigorously documented only in North America and Europe.

The mode of spread of LCM virus in most sporadic human cases is unknown , but studies suggest direct contact with rodents or spread by infected aerosols.

The clinical disease produced by LCM is a meningitis, a meningo-encephalitis, or a self-limited febrile illness.

Arthritis, parotiditis, orchitis, and myopericarditis have also been reported.

Fatal cases in humans are extremely rare.

In monkeys infected by inhalation, virus can be recovered from the lungs and hilar lymphnodes 2 days after infection.

Lymphocytic meningitis is often the most conspicuous lesion, but hemorrhagic necrosis may also be seen in liver, kidney, heart, adrenal gland, and other organs.

The spleen and lymph nodes show hyperplasia.

Congenital Lymphocytic choriomeningitis virus infection:

Lymphocytic choriomeningitis virus (LCMV) is an underdiagnosed fetal teratogen.

This diagnosis should be considered for infants and children with unexplained hydrocephalus, micro- or macrocephaly, intracranial calcifications, chorioretinitis, and nonimmune hydrops.

The immunofluorescent antibody test is the only reasonable, commercially available, screening diagnostic tool.

The differential diagnosis of congenital LCMV infection includes  toxoplasmosis , rubella , cytomegalovirus , herpes simplex virus , enteroviruses, human parvovirus B19, and syphilis.

                   

Abstracts:

A-to-G Hypermutation in the Genome of Lymphocytic Choriomeningitis Virus.J Virol. 2006 Oct 4;

Congenital lymphocytic choriomeningitis virus: an underdiagnosed cause of neonatal hydrocephalus.Pediatr Infect Dis J. 2006 Jun;25(6):560-2.

Altered central nervous system gene expression caused by congenitally acquired persistent infection with lymphocytic choriomeningitis virus.J Virol. 2006 Sep;80(18):9082-92

Transmission of lymphocytic choriomeningitis virus by organ transplantation.N Engl J Med. 2006 May 25;354(21):2235-49.

Congenital lymphocytic choriomeningitis virus infection: decade of rediscovery.Clin Infect Dis. 2001 Aug 1;33(3):370-4. Epub 2001 Jul 5

Lymphocytic choriomeningitis virus: an underdiagnosed cause of congenital chorioretinitis.Am J Ophthalmol. 2000 Aug;130(2):209-15

Congenital lymphocytic choriomeningitis virus syndrome: a disease that mimics congenital toxoplasmosis or Cytomegalovirus infection.Pediatrics. 1997 Jul;100(1):E9

 
August  2009
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