Acanthomas are benign tumours of the epidermal keratinocytes.
2) Acantholytic acanthoma
The benign acanthomas are the benign tumours of epidermal keratinocytes.
[ The benign acanthomas. Brownstein MH. J Cutan Pathol. 1985 Jun-Aug;12 (3-4):172-88.
An important, yet neglected, problem in dermatopathology, is the evaluation of the benign acanthomas, the benign tumors of epidermal keratinocytes. The benign acanthomas may be simulated by lesions which are not benign (e.g. actinic keratosis), not tumors (e.g. normal plantar skin), or are not epidermal (e.g. dermatofibroma). In addition to normal (epidermoid) keratinization (e.g., seborrheic keratosis and related conditions), the variants of the benign acanthomas show a wide range of aberrant keratinization, including epidermolytic hyperkeratosis (epidermolytic acanthoma), dyskeratosis (warty dyskeratoma), acantholysis (acantholytic acanthoma), cornoid lamellation (porokeratosis), lichenoid hyperplasia (lichen planus-like keratosis), and absence of keratinization (clear cell acanthoma). ]
A disseminated form has been described.
Histology shows epidermolytic hyperkeratosis.
[ Epidermolytic hyperkeratosis is an abnormality of epidermal maturation. Features include compact hyperkeratosis, granular and vacuolar degeneration of the cells of the spinous and granular layers. ]
This is a solitary tumour arising on the trunk of older patients .
Multiple lesions have been reported in a renal transplant recipient.
Histology reveals hyperkeratosis, papillomatosis, acanthosis and variable acantholysis together with cleft formation.
Histologically, this lesion resembles a pigmented seborrheic keratosis.
The features include acanthotic epidermis, composed of basaloid and spinous cells together with scattered dendritic melanocytes.
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