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Pathology of Argentine Hemorrhagic Fever (caused by Junin Virus)

Dr Sampurna Roy MD     




Argentine hemorrhagic fever (AHF) is a viral disease caused by Junin virus and characterized by hematologic and neurological involvement.

(Arenaviruses include Junin virus, Lassa virus, Machupo virus, Guanarito virus and Sabia).  

Visit: Arenavirus Lassa Fever ; Viral hemorrhagic fevers

It is a severe illness whose symptoms resemble those of Korean Hemorrhagic Fever .

An epidemic developed in rural agricultural areas and villages northwest of Buenos Aires in 1958.

The virus is found naturally in wild rodents and may be transmitted in food or contaminated airborne dust.

The main hematologic features are leukopenia, thrombocytopenia, and bone marrow hypoplasia.

Hemorrhagic Fever Viruses as Biological Weapons (full article-JAMA)


Further reading:

Viral Hemorrhagic Fevers | CDC Special Pathogens Branch

Arenaviruses | CDC Special Pathogens Branch

Argentinian hemorrhagic fever: essential data

Antiviral treatment of Argentine hemorrhagic fever.

Argentine Hemorrhagic Fever Alterations of the Complement System and Anti-Junin-Virus Humoral Response

A longitudinal study of Junin virus activity in the rodent reservoir of Argentine hemorrhagic fever.

Protective Efficacy of a Live Attenuated Vaccine against Argentine Hemorrhagic Fever




Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)








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